2-Chloronicotinic acid (CAS 2942-59-8) is a key pharmaceutical and agrochemical intermediate. The 2-chloro and 3-carboxyl handles enable SNAr substitution, cross-coupling and amidation to build substituted pyridines and heterocyclic APIs.
Specifications
| Parameter | Value |
|---|---|
| Appearance | White crystalline powder |
| Assay (HPLC) | 99.5% min |
| 6-Chloronicotinic acid | 0.10% max |
| 2-CNA dimer | 0.10% max |
| Correlated each other impurity | 0.10% max |
| Sulphate | 0.10% max |
| Loss on drying | 0.30% max |
| Residue on ignition | 0.20% max |
| Melting range | >177 °C (decomposes) |
| Solution clarity | Clear (0.5 mol/L aqueous NaOH) |
Applications
- Pharmaceutical intermediates – substituted pyridines, heterocyclic APIs, esters and amides.
- Agrochemical intermediates – chloronicotinic acid fragments for neonicotinoid-type chemistry.
- Specialty organics – ligands and fine-chemical building blocks.
Storage and Packaging
Store sealed, cool and dry, away from moisture, strong bases and oxidizers. Standard packaging: 25 kg fibre drums or bags with PE liner.
FAQ
Is 2-chloronicotinic acid the same as 6-chloronicotinic acid? No – they are regioisomers with different reactivity; each is a separate specification item.
Can you supply custom derivatives? Yes – custom esters, amides and 2-substituted nicotinates can be made to specification.
See the full guide for chemistry, production and applications.
