Dimethyl sulfate (DMS, CAS 77-78-1), also known as sulfuric acid dimethyl ester, is a clear and colorless liquid and one of the most important industrial methylating agents, used in pharmaceuticals, agrochemicals, dyes and specialty chemicals.
Specifications
| Appearance | Clear and colorless liquid |
| Assay | 99.0% min |
| Acidity | 0.3% max |
| CAS number | 77-78-1 |
| Molecular formula | C2H6O4S |
| Molecular weight | 126.13 g/mol |
Applications
- Methylating agent for pharmaceutical and agrochemical synthesis.
- Quaternization of amines for surfactants, textile and personal care chemicals.
- Methylation in dyes, pigments and fine chemicals.
Handling and Storage
Dimethyl sulfate is a highly toxic and corrosive liquid and a suspected carcinogen. It must be handled in closed systems with strict personal protective equipment, adequate ventilation and immediate access to emergency response procedures. Store in a cool, dry, well-ventilated place away from moisture, alkalis and oxidants, with the container tightly closed.
Chemical Structure
COS(=O)(=O)OC
FAQ
What is dimethyl sulfate used for? It is used mainly as a methylating agent in pharmaceutical, agrochemical, dye and surfactant production.
How should dimethyl sulfate be stored? Keep it cool, dry and tightly sealed, away from moisture and alkalis; handle only with strict safety controls.




