MeOTf (Methyl trifluoromethanesulfonate), CAS 333-27-7

Methyl trifluoromethanesulfonate (MeOTf) (CAS 333-27-7) is a speciality research chemical, supplied at 98.5% purity as colorless liquid, with a batch COA and SDS issued against the specification you agree.

Specifications

Property Specification
Appearance colorless liquid
Purity 98.5%
CAS number 333-27-7
Molecular formula C2H3F3O3S
Molecular weight 164.11 g/mol
PubChem CID 9526
SMILES COS(=O)(=O)C(F)(F)F

Where it is used

  • Very strong methylating agent; fuming liquid, handle under inert gas.
  • Laboratory and process research where a defined, documented grade is required
  • Scale-up screening, where the same chemistry is later transferred to a larger batch

Reading the specification

This is a research-scale speciality product, and the specification reflects that: assay by HPLC or GC is the primary line, with appearance used as the practical ageing indicator. For air- or moisture-sensitive items in this group the packaging and the headspace matter as much as the assay, and for the strongly alkylating or pyrophoric items the handling section below is part of the product, not an accessory to it.

Packaging and supply

Supplied in research quantities from 1 g and 5 g through 25 g and 100 g, with scale-up to bulk packed under nitrogen or argon where the product allows it. Every lot ships with a batch COA and the current SDS, FOB or CIF against destination. If you need a specific assay method, a water limit, an enantiomeric purity figure or a metal-residue limit, state it at enquiry stage – the batch documentation is issued against the specification you agree.

Hazard notice: This is a highly reactive methylating agent and a toxic, corrosive liquid. Methyl trifluoromethanesulfonate reacts violently with water and alcohols, fumes in moist air, and is a suspected genotoxin by alkylation chemistry – work in a fume hood with a face shield and butyl or fluoroelastomer gloves, keep the container under inert gas, and quench residues carefully onto crushed ice and bicarbonate. Do not use syringes or septa that are not rated for this reagent. Refer to the SDS before any transfer.

Related products

PolyBlueChem supplies Methyl trifluoromethanesulfonate (CAS 333-27-7) at 98.5% purity, colorless liquid, from gram to kilogram scale with per-batch COA and SDS. Send the quantity, the assay method and the purity profile your process needs, and we will confirm the grade and the documentation.

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