Buying (R)-(+)-2-methyl-2-propanesulfinamide (CAS 196929-78-9) for asymmetric synthesis means the chiral purity matters as much as the chemical purity. This guide explains what to specify, what the COA must show, and how to store the reagent.
1. The Specification Sheet
| Parameter | Value | Why it matters |
|---|---|---|
| Appearance | White to off-white crystallization | Visual QC |
| Purity (HPLC) | 99.0% min | Chemical purity, by-product control |
| Chiral purity (LC) | 99.0% min | Enantiomeric purity – controls stereoselectivity |
2. What a COA Should Show
- HPLC purity with method and chromatogram reference.
- Chiral LC result – enantiomer ratio (R:S) or % ee.
- Appearance, batch number, retest date.
- Optional: residual solvents, water content, specific rotation.
3. Enantiomer Selection
Choose the (R) form (196929-78-9) or (S) form (343338-28-3) according to the target amine’s configuration. Qualify both if your route portfolio needs flexibility.
4. Packaging and Storage
- Sealed containers under inert atmosphere; protect from moisture, oxygen and light.
- Store cold (refrigerated) and dry; allow to equilibrate to room temperature before opening to avoid condensation.
- Shelf life and retest date per supplier COA.
5. FAQ
Can I get gram-scale quantities to start?
Yes – gram to kilogram quantities are available; contact us with your required quantity and enantiomer.
Is specific rotation reported?
Suppliers can report optical rotation in addition to chiral LC; request it if your specification requires.
6. References and Further Reading
- Supplier COA and MSDS for the specific grade.
- Literature on chiral sulfinamide auxiliaries.
This article is published for industrial and technical reference by PolyblueChem. Verify against the supplier’s COA and applicable standards.
See our sulfinamide chemistry guide and the chiral amine synthesis guide. PolyblueChem supplies (R)-(+)-2-methyl-2-propanesulfinamide (CAS 196929-78-9) – contact us for specifications and quotations.